Strydom N, et al. - Suboptimal response in treating tuberculosis (TB) may be due to lower drug penetration into the various lung lesions formed by the host immune system where bacteria remain in isolated areas inaccessible by the drug, so researchers developed a mathematical model for seven major drugs (rifampin, isoniazid, linezolid [LZD], moxifloxacin [MFX], clofazimine [CFZ], pyrazinamide, and kanamycin) using actual patient data, describing the amount and rate of drug penetration in nine TB lesions in which mycobacteria reside. According to results, inadequate levels of drugs at the site of the disease are seen with most TB drugs due to poor cavitary lesion penetration. For patients presenting with caseous lesions, a combination of CFZ and MFX or CFZ and LZD would be optimal for a cure at the site of infection.