van Etten ES, Kaushik K, Jolink WMT, et al. - Researchers investigated the potential trigger factors for vessel rupture resulting in intracerebral hemorrhage (ICH) onset.

• A total of 149 patients (mean age 64, 66% male) diagnosed with ICH between July 1, 2013, and December 31, 2019, were interviewed.

• Occurrence of a lobar hemorrhage was recorded in 67 (45%), a deep hemorrhage in 60 (40%), a cerebellar hemorrhage in 19 (13%), and an intraventricular hemorrhage in 3 (2%) patients.

• In general, there was an increased risk of ICH within an hour after caffeine consumption, within an hour after coffee consumption alone, within an hour after lifting > 25 kg, within an hour after minor head trauma, within an hour after sexual activity, within an hour after straining for defecation, and within an hour after vigorous exercise.

• In addition, an increased risk for ICH was recorded within 24 hours after flu-like disease or fever.

• The RR for deep ICH was 3.5 and for lobar ICH was 2.0 within an hour after Valsalva maneuvers.

• Overall, this study revealed one infection and several blood pressure related trigger factors for ICH onset