Chen JY, et al. - Researchers here evaluated the impact of TCA use on fibrosis progression and development of hepatocellular carcinoma (HCC) among HCV-infected persons using the Electronically Retrieved Cohort of HCV Infected Veterans. Outcomes here revealed an association of tricyclic antidepressants use with decreased fibrosis progression and lower risk of developing cirrhosis. Supportive evidence was thus gained suggesting the beneficial effects of tricyclic antidepressants on progression of liver fibrosis in patients with chronic HCV infection.