Liang C, Zhang X, Zhou L, et al. - This study sought to evaluate the trends and relationship between antibacterial consumption and carbapenem resistance in Gram-negative bacteria from 2012 to 2019 in a tertiary-care teaching hospital in southern China. Researchers conducted a retrospective study including data from hospital-wide inpatients collected between January 2012 and December 2019. They categorized antibacterials according to the Anatomical Therapeutic Chemical classification system. They examined trends in antimicrobial usage and resistance by linear regression, while Pearson correlation analysis was used for evaluating relationships. These outcomes demonstrated significant correlations between consumption of antibiotics and carbapenem resistance rates in Gram-negative bacteria. The findings revealed that implementing proper management strategies and decreasing the unreasonable use of antibacterial drugs may be an effective measure to decrease the spread of carbapenem-resistant Gram-negative bacteria, which should be confirmed by future trials.