Jitkritsadakul O, et al. – This randomized sham–controlled trial aimed to examine the efficacy of electrical muscle stimulation (EMS) as a treatment of resting hand tremor delivered using Tremor's glove. In suppressing resting hand tremor, EMS–based Tremor's glove was effective in Parkinson's disease (PD) patients. Tremor's glove was light–weight with a good safety profile, making it a future potential therapeutic option for PD patients with medically refractory tremor.

• The authors randomly allocated 30 PD patients with medically refractory resting tremor to a Tremor's glove group (n = 15) or a sham glove group (n = 15).
• They placed gloves on the most tremulous hand for 30 min per testing session.
• They evaluated demographics, clinical rating scales, and tremor parameters (RMS of angular velocity and angular displacement, peak magnitude, and frequency) before and during stimulation.
• They performed correlations with validated clinical rating scales.

• No statistically significant differences were observed between groups in demographics, rating scales, or tremor parameters.
• The authors found a significant reduction in RMS angular velocity (as a percentage) in every axis and peak magnitude in axis (x-, y-) and UPDRS tremor score, with Tremor's glove compared to the sham groups (p < 0.05, each) during stimulation.
• They observed significant moderate correlations between a percentage reduction of RMS angular velocity in every axis and UPDRS tremor scores.
• After stimulation, mean duration of tremor reduction was 107.78 ± 104.15 s.
• There were no serious adverse events.