Trem-1 neutrophil activation pathway is suppressed in eosinophilic nasal polyps
American Journal of Rhinology & Allergy Jul 09, 2018
Wu D, et al. - Experts evaluated the neutrophil activation pathways in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). They assessed the protein expression using Student’s t test and Benjamini–Hochberg procedures followed by the application of Ingenuity Pathway, MetaCore, and Genemania bioinformatics analyses. Results demonstrated a significant suppression of TREM-1-associated neutrophilic signaling pathway protein in eosinophilic CRSwNP. Moreover, they noted a significant positive association of the fold change (FC) of the studied proteins’ expression with FC of their mRNA expression.
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