Rash D, et al. - In this retrospective study, experts compared the clinical outcomes among 51 consecutively presenting patients-38 men and 13 women, aged 46 to 74 years (median: 57)-with locally advanced human papillomavirus (HPV)-negative oropharyngeal cancer who were treated with either primary surgery followed by postoperative radiotherapy or definitive chemoradiotherapy alone. For locally advanced HPV-negative oropharyngeal cancer, similar outcomes were resulted by treatment with either primary surgery followed by postoperative radiotherapy or chemoradiotherapy (CRT).