Forton FMN, et al. - In this retrospective observational study involving 394 patients, researchers assessed the effect of topical benzyl benzoate [BB] (+crotamiton) treatment on Demodex densities (Dds) and clinical symptoms of rosacea and demodicosis and compared three BB treatment regimens. Three BB (+crotamiton) treatment regimens were compared for this investigation: 12% once daily, 12% twice daily and 20% once daily. According to results, the total Dd (SSSB1+2) had decreased by 72.4 ± 2.6% from the initial value across the whole cohort at an average of 2.7 months after treatment start. Compared with other doses, the 12% once daily regimen was less efficient and had poorer compliance than the 12% twice daily regimen. Overall, the authors concluded that topical BB (+crotamiton) treatment can be an effective treatment for rosacea as well as demodicosis, indirectly supporting a key role of the mite in rosacea pathophysiology. The two dose regimens that were higher than the lower dose were more effective.