Michels T, et al. - Researchers performed a retrospective observational study examining the influence of local anesthetics (LAs), in low concentration and very small quantities, on peripheral pain. For this purpose, they analyzed a total of 127 consecutive patients (43 with cervico-brachial, 12 with intercostal and 72 with lumbo-sciatic pain) who received an identical treatment during a period of 2 years. The treatment consisted of LAs applied in 4–8 sessions on average to a fixed set of epidermal, epithelial and periosteal locations. At the end of therapy, a complete remission was noted in 53 (41.7%) patients (reduction of pain 100%), a partial remission with >90% reduction of pain in 23 patients (18.1%) and a pain reduction of 30%–90% in 50 patients (39.4%). This establishes the high efficacy of LAs in low concentration and small quantities in the treatment of peripheral pain.