Floridia D, et al. - Via reporting the use of high-frequency (10 kHz) spinal cord stimulation (HFSCS) in a patient with brachial plexus injury (root avulsion), researchers appraised the efficacy of HFSCS in root avulsion. In addition, they examined the putative neurophysiological mechanisms of HFSCS. In this first report, HFSCS was exhibited to be a useful and safe option for the patient. They identified that HFSCS may either block large-diameter fibers or stimulate medium-/small-diameter fibers, thereby leading to the induction of analgesia without paresthesia, possibly by diminishing the activation of the wide-dynamic-range neurons. Further, HFSCS appeared modulating spinal inhibitory mechanisms and the descending corticospinal inhibitory output. Therefore, for treating refractory pain following root avulsion, HFSCS appears to be a potential effective option.