Guan J, et al. - In this case report, researchers presented a 48-year-old female patient with radiation-induced abdominal wall angiosarcoma who showed a dramatic response to low-dose apatinib, a small tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2. The abdominal wall tumors exhibited repeated rupture and bleeding, with poor wound healing. Laboratory findings identified the negative serum tumor markers CEA, CA 125, CA 15–3 and CA 19–9 on evaluation. According to results, the abdominal wall lesions that had previously ruptured stopped bleeding and displayed significant shrinkage at the 6-month follow-up visit. This case indicates that apatinib can be an effective and sensitive treatment for angiosarcoma caused by radiation, even at the lowest dosage, without exacerbating lesion bleeding.