Shah GB, et al. - Experts systematically reviewed the use of dornase on chronic rhinosinusitis (CRS) in cystic fibrosis (CF) patients. For this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed. As per data, the sinonasal symptoms appeared to improve in CF patients to a greater degree with topical intranasal dornase than saline alone. The impact on other outcomes was less clear. Authors noted variable impact on pulmonary function and radiographic and endoscopy findings.