Rodriguez-Galindo C, Krailo MD, Krasin MJ, et al. - Given that the treatment of childhood nasopharyngeal carcinoma has been adapted from adult regimens and there exist limited pediatric-specific studies, therefore, researchers assessed the influence of induction chemotherapy (IC) and concurrent chemoradiotherapy (CCR) in the ARAR0331 study. Three cycles of IC with cisplatin and fluorouracil, followed by CCR with three cycles of cisplatin, were administered to patients with American Joint Committee on Cancer stages IIb to IV. They administered 61.2 Gy to the nasopharynx and neck to patients with complete or partial response to IC, and administered 71.2 Gy to patients with stable disease. The 5-year event-free survival (EFS) was estimated to be 84.3% and 5-year overall survival was identified to be 89.2%. Advanced disease and a high proportion of black children and adolescents defined patients in ARAR0331. Excellent results were achieved with treatment with IC and CRT. It was possible to decrease a radiation dose for patients responding to IC. Despite the results being comparable, a trend toward reduced EFS was observed for patients selected to receive fewer doses of cisplatin during CCR.