Eng TY, et al. - Researchers report their institutional experience with urethral cancer treated with various treatment modalities. A total of 31 patients, stratified by sex, histologic type, stage, date of diagnosis, type of treatment, and last follow-up, and treated for primary cancer of the urethra from 1958 to 2008, were retrospectively reviewed. Early stage cases were designated as Tis-T2N0M0 and advanced cases were designated as T3-4, N+ or M+. Men comprised the majority of early stage cases (M:F=8:6) and women comprised the majority of advanced stage cases (M:F=5:12). Squamous cell carcinoma was documented as the most common histology for both early and advanced stage cases. Patients with early stage urethral cancers did well with single modality therapy, whereas combined modality therapy could be beneficial for patients who presented with advanced cancers. At last follow-up, 8 of the 14 cases of early stage cancer were disease free, whereas only 5 of 17 with advanced cancers had no apparent disease at last follow-up.