Ando T, Aoi S, Ashraf S, et al. - By analyzing literature data, researchers compared transradial (TR) percutaneous coronary intervention (PCI) vs transfemoral (TF) PCI in terms of efficacy and safety in left main (LM) lesion. They selected studies that described the comparable results between both approaches, from PUBMED, EMBASE, and Cochrane database. They used the Mantel–Haenszel method to calculate odds ratio and 95% confidence interval. The quantitative meta-analysis was performed including 8 studies. Findings revealed lower bleeding risk in relation to TR-PCI. With regard to procedural success rate, target lesion revascularization, myocardial infarction, stent thrombosis, and all-cause death, TR-PCI was similar to TF-PCI. TR approach was recognized as attractive alternative access over TF approach in LM-PCI, in the presence of favorable operator experience and anatomical complexity.