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Transplant outcomes in kidney recipients with lupus nephritis, and systematic review

Lupus Evidence based | Mar 11, 2020

Kim JE, Kim YC, Min SI, et al. - A systematic review was carried out to present the transplant outcomes in kidney recipients with lupus nephritis. This study retrospectively analyzed a sum of 1,848 Korean kidney recipients who underwent transplantation between 1998 and 2017 at two tertiary referral centers. Twenty-eight recipients with lupus nephritis (LN), and 50 control recipients matched by age, gender, and donor type, were correlated with respect to graft and patient survival among them. They combined the data with 17 previous cohort studies in which the graft survival of recipients with LN was described in detail. The graft failure (GF) occurred in 10.7% and 16.0% of LN and control recipients, respectively during the median follow-up period of 9.5 years (maximum 21 years). There were no differences in the rates of GF and death-censored graft failure or patient survival between the two groups. Between the two groups, the risks of acute T cell-mediated and antibody-mediated rejection were also similar. Between LN and control recipients, the pooled analysis explicated similar 1- and 5-year graft survival rates. The results showed that kidney transplantation is an acceptable option in patients with concurrent LN and end-stage renal disease (ESRD).
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