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Transplant outcomes in kidney recipients with lupus nephritis, and systematic review

Lupus Feb 06, 2020

Kim JE, Kim YC, Kim SI, et al. - Researchers retrospectively examined a sum of 1,848 Korean kidney recipients who underwent transplantation between 1998 and 2017 at two tertiary referral centers. Among them, 28 recipients with lupus nephritis (LN), and 50 control recipients matched by age, gender, and donor type, were correlated with respect to graft and individual survival. The data showed that graft failure (GF) occurred in 10.7% and 16.0% of LN and control recipients, respectively during the median follow-up period of 9.5 years (maximum 21 years). There were no differences in the rates of GF and death-censored graft failure or individual survival between the two groups. Between the two groups, they found similar risks of acute T cell-mediated and antibody-mediated rejection. In this pooled analysis, 1- and 5-year graft survival rates were similar between LN and control recipients. In individuals with concurrent LN and end-stage renal disease, kidney transplantation is an acceptable option.
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