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Transient hypothyroidism and autoimmune thyroiditis in children with chronic hepatitis C treated with pegylated-interferon-α-2b and ribavirin

The Pediatric Infectious Disease Journal Mar 26, 2018

Serranti D, et al. - Experts resolved to examine the appearance and timing of thyroid dysfunction and antithyroid autoimmunity in children with chronic hepatitis C (CHC) treated with pegylated interferon (IFN)-α-2b and ribavirin (RBV). It was determined that the subclinical hypothyroidism was common in the study cohort but in maximum cases, it appeared to be transient. Findings displayed that the autoimmune thyroiditis, which was less common, generally persisted after treatment completion. Hence, careful monitoring was recommended via thyroid function in individuals presenting with antithyroid autoantibodies and thyroid dysfunction during and after pegylated IFN-α–based treatment.
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