Sanchez-Caro JM, de Celis Ruiz E, Arribas AB, et al. - Findings showed a high risk of lobar intracerebral hemorrhage (ICH) and death in patients presenting with cerebral amyloid angiopathy (CAA)-associated transient focal neurological episodes (TFNEs). Motor TFNEs and use of antithrombotics after a TFNE, in many patients due to misdiagnosis, were identified as risk factors for ICH, and thus correct diagnosis and differentiating this condition from transient ischemic attacks is important.

• This is a pooled analysis of a systematic review and individual participant meta-analysis and a hospital-based cohort comprising 248 adults with CAA–associated TFNEs.

• An increase in risk of lobar intracerebral hemorrhage was observed in relation to motor TFNEs (odds ratio, 2.08) and antithrombotics use (odds ratio, 3.61).

• Higher mortality rates were reported in relation to intracerebral hemorrhage and cortical superficial siderosis (odds ratio, 3.01 and 3.20, respectively).