Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas
Modern Pathology Oct 07, 2018
Di Napoli A, et al. - In this study, researchers performed gene expression profiling of microdissected breast implant-associated anaplastic large cell lymphoma samples and compared their profiles with those previously obtained from normal T-cells and other peripheral T-cell lymphomas, and validated expression of selected markers via immunohistochemistry. Most breast implant-associated anaplastic large cell lymphomas were found to exhibit an activated CD4+ memory T-cell phenotype, which is associated with CD25 and FoxP3 expression. In gene ontology analyses, breast implant-associated anaplastic large cell lymphomas showed upregulation of genes involved in cell motility programs (eg, CCR6, MET, HGF, CXCL14) vs normal CD4+ T-cells, and there was upregulation of genes involved in myeloid cell differentiation (eg, PPARg, JAK2, SPI-1, GAB2) and viral gene transcription (eg, RPS10, RPL17, RPS29, RPL18A) compared wotj other types of peripheral T-cell lymphomas. These findings, thus, provided further support that breast implant-associated anaplastic large cell lymphoma denotes a distinct peripheral T-cell lymphoma entity.
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