Callai EMM, et al. - Researchers examined the impact of Transcranial direct current stimulation (tDCS) on facial allodynia produced by chronic constriction of the infraorbital nerve (CCI-ION) and on the brainstem levels of TNF-α, NGF, IL-10, and serum LDH in rats. They noticed a decline in mechanical threshold due to CCI-ION, 14 days after surgery. They noticed a reverse in this impact by tDCS therapy, with the mechanical threshold retiring to basal levels at 24 hr after the completion of treatment which continued for 7 days after the end of therapy. They also recorded a decline in LDH serum levels due to tDCS than in the control group. They concluded communication between pain and treatment with regard to brainstem levels of NGF, TNF-α, and IL-10. Overall, they preferred tDCS, a possible therapy in the treatment of trigeminal pain.