Meng Y, et al. - The proposition examined was that tranexamic acid would reduce blood loss to a greater extent in obese patients than in those of normal weight. The enrollment consisted of patients with knee osteoarthritis treated with total knee arthroplasty (TKA) from October 2013 to March 2015, who were separated into tranexamic, non-tranexamic, obese, and non-obese groups. Yielded data illustrated that tranexamic acid could reduce occult blood loss and tourniquet time in obese patients to a greater extent than in patients of normal weight. Hence, an additional benefit could be gained from the tranexamic acid by obese knee osteoarthritis patients undergoing TKA.