Hong GJ, Wilson LA, Liu J, et al. - This study was sought to evaluate if tranexamic acid (TXA) use might be correlated with a lower incidence of periprosthetic joint infection (PJI) following orthopedic surgery. Between 2012 to 2016, researchers evaluated the Premier Healthcare database for ICD-9 codes corresponding to elective inpatient primary total hip replacement (THR) or total knee replacement (TKR), TXA administration on the day of surgery, and PJI during the hospital stay or within 90 days. A multilevel multivariable logistic regression (SAS version 9.4. SAS Institute, Cary, NC) was conducted to ascertain whether TXA administration or other covariates were a significant predictor of infection. In the analysis, 46.0% received TXA on the day of surgery. 0.13% developed PJI within 90 days among 914,990 total joint arthroplasty patients. In total knee and total hip arthroplasty, the administration of TXA on the day of surgery was correlated with a statistically significant decreased odds of PJI in the first 90 days. The data considered that TXA might play an important role in our attempts to decrease PJI after joint arthroplasty. The exact mechanisms and ideal dosage by which TXA can contribute to such a reduction required future evaluation.