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Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: A prospective cohort study

BMC Pregnancy and Childbirth Feb 18, 2018

Bärebring L, et al. - This study was planned to assess the associations between vitamin D status in early and late pregnancy with neonatal small for gestational age (SGA), low birth weight (LBW) and preterm delivery. In addition, researchers looked for associations between vitamin D status and pregnancy loss. In this study, a higher odds of SGA and LBW were evident in association with Vitamin D deficiency in late pregnancy. Lower 25-hydroxyvitamin D (25OHD) in early pregnancy was only associated with pregnancy loss. From early to late pregnancy, vitamin D status trajectory showed an inverse association with SGA, LBW and preterm delivery. Women with the highest increment in 25OHD showed the lowest odds. Thereby suggesting that in a healthy pregnancy, both higher vitamin D status in late pregnancy and gestational vitamin D status trajectory could play a role.
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