Xiang X, et al. - In 15,661 participants aged over 50 years from the U.S. Health and Retirement Study, depression trajectories and correlates were examined. Researchers used the Composite International Diagnostic Interview to assess major depression and used a group-based trajectory modeling enhanced to account for nonrandom attrition to identify depression trajectories. Predictors of depression trajectories were examined via conducting multinomial logistic regression. Outcomes revealed chronic major depression in a small but nonignorable proportion of middle-aged and older adults. They identified four depression trajectory groups: “never” (85.8%), “increasing” (6.3%), “decreasing” (3.2%), and “persistently moderate/high” (4.7%). The risk for unfavorable depression trajectories was consistently higher in correlation to initial symptom severity and chronic disease burden and hence they suggest these as potential targets for screening and intervention.