Dayimu A, Wang C, Li J, et al. - Researchers characterized longitudinal trajectories of lipid profile (LDL cholesterol, HDL cholesterol, and triglycerides) jointly, and determined how they can influence incident cardiovascular disease (CVD). Participants included 9,726 people aged 20-58 years who had lipid profiles repeatedly assessed 3 to 9 times. The investigators used a multivariate latent class growth mixture model to determine three distinct trajectories: inverse U-shape (18.72%; n = 1,821), progressing (66.03%; n = 6,422), and U-shape (15.25%; n = 1,483). For the progressing and inverse U-shape classes, relative to the U-shape class, the adjusted HRs and 95% CIs were 1.33 (1.05–1.68) and 1.49 (1.14–1.95), respectively. Findings revealed a significant influence of lipids profile trajectories on CVD risk. Concerning incident CVD, the authors noted that the crucial period is the age between 20 and 42 years.