Duncan MS, et al. – In this study, researchers examined how atherosclerotic cardiovascular disease (ASCVD) and mortality risk may be influenced by lipid trajectories throughout adulthood. The study sample consisted of 3,875 Framingham Offspring participants who completed ≥ 1 examination between 1979 and 2014. Factors that were identified to have correlations with higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-high-density lipoprotein cholesterol (non-HDL-C), and lower HDL-C concentrations included male sex, greater body mass index, and smoking. The investigators found five TC, HDL-C, and LDL-C trajectories, and four triglyceride and non-HDL-C trajectories. Using a longitudinal modeling technique, unfavorable lipid trajectories over 35 years were identified as a risk factor for a higher ASCVD and mortality risk later in life.