Chen T, et al. - The relation of Fusobacterium nucleatum (F. nucleatum) amount to thymocyte selection-associated high-mobility group box (TOX) protein expression and CD4+ T cell density was evaluated in 138 human colorectal tissues. Findings revealed a negative correlation of F. nucleatum amount with TOX expression and CD4+ T cell density. Compared to non-cancer tissues, different stage of colon cancers demonstrated decreased TOX expression. A positive correlation of CD4+ T cell density with TOX expression in colorectal tissues was noted.