Park JY, Kang MJ, Kim BG, et al. - Researchers conducted this retrospective cohort to assess topographic changes in choroidal thickness during the development of choroidal neovascularization (CNV) in treatment-naive age-related macular degeneration (AMD) and to examine the value of such changes as a predictive tool of CNV development. They involved 86 eyes that developed CNV from intermediate AMD, 43 eyes with intermediate AMD, and 36 eyes without AMD. Every 6 months before CNV was detected, patients with intermediate AMD underwent spectral-domain optical coherence tomography using enhanced depth imaging mode. The development of choroidal neovascularization followed the choroidal thickening of the corresponding subfield. Regular choroidal thickness measurement can assist in the prediction of CNV.