Byon I, Ji Y, Alagorie AR, et al. - Researchers conducted this cross-sectional study to assess the choriocapillaris (CC) flow deficit in eyes with hyporeflective cores (HCs) inside drusen in eyes with intermediate age-related macular degeneration. Using a Cirrus HD-optical coherence tomography (Carl Zeiss Meditec, Dublin, CA), intermediate age-related macular degeneration individuals underwent optical coherence tomography and optical coherence tomography angiography. Fifty eyes were involved in this analysis. According to findings, intermediate age-related macular degeneration eyes with HCs showed more impaired CC flow, compared with those without this featured. The CC was also affected more severely with HCs immediately below these drusen. Such results illustrate that the presence of HCs can be an indicator of a more advanced disease phenotype.