Riedl S, Cooney L, Grechenig C, et al. - This study was sought to assess morphologic photoreceptor integrity during anti-vascular endothelial growth factor (anti-VEGF) therapy of neovascular age-related macular degeneration and compared these findings with disease morphology and function. Researchers conducted a post hoc analysis on spectral-domain optical coherence tomography data of 185 patients, acquired at baseline, Month 3, and Month 12 in a multicenter, prospective trial. They manually evaluated the loss of the ellipsoid zone (EZ) in all-optical coherence tomography volumes. During anti-VEGF therapy of neovascular age-related macular degeneration, improvement of EZ integrity occurred predominantly in the fovea. It was shown that photoreceptor integrity associated with best-corrected visual acuity. The results revealed that ellipsoid zone integrity was preserved in areas of subretinal fluid (SRF) and exhibited deterioration upon SRF resolution.