Buchalter DB, Kirby DJ, Teo GM, et al. - Researchers here examined if incidence of early periprosthetic joint infection (PJI) can be reduced with using vancomycin powder and dilute povidone-iodine lavage (VIP) in all primary total knee arthroplasty (TKA) patients, regardless of preoperative risk. They reviewed data of patients with PJI from an infection database of primary TKAs conducted before a VIP protocol was implemented (January 2012-December 2013), during a time when only high-risk TKAs were administered VIP (January 2014-December 2015), and when all TKAs were administered VIP (January 2016-September 2019) at an urban, university-affiliated, not-for-profit orthopedic hospital. Analysis revealed reduction in early PJI incidence after primary TKA in correlation with VIP administration; this was observed regardless of preoperative risk. The literature supports VIP as a safe and cost-effective option suggesting it to be a value-based intervention.