Alvandipour M, et al. - Researchers evaluated the efficacy and the adverse effects of topically applied minoxidil in chemical sphincterotomy of chronic anal fissure in comparison with topical diltiazem. Researchers performed a double-blind, randomized clinical trial including 88 patients with chronic anal fissure aged between 15 and 65 years and randomized them to either 0.5% minoxidil cream or 2% diltiazem cream twice daily for 2 weeks. As per observations, topically administered minoxidil and diltiazem were equally effective in the treatment of chronic anal fissure with low frequency of adverse effects. Thereby suggesting that for chemical sphincterotomy of anal fissure, topically administered minoxidil can be considered as an agent, however, the itching at the beginning of the treatment might affect the adherence of the patient to treatment.