Molina GE, et al. - Researchers studied the utility and effectiveness of a topical combination of fluorouracil and calcipotriene as palliative treatment for refractory extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma. For this retrospective case series, three females with recurrent, refractory EMPD were treated with a 1:1 mixture of fluorouracil, 5%, cream and calcipotriene, 0.005%, cream or ointment. The treatment was well tolerated, and clinical improvement was followed in all patients with a demonstrated histopathological response in two of the women. Even after aggressive surgical management, EMPD often recurs and can be refractory to many topical and locoregional therapies. For patients with recurrent, refractory EMPD, palliative treatment with a combination of fluorouracil and calcipotriene may be a viable option.