Ma Z, Kochergin N, Olisova O, et al. - This research sought to correlate the therapeutic effectiveness and tolerability of an isotretinoin treatment course with GDP-20 (granulysin-derived peptides) vs the conventional isotretinoin monotherapy prescribed to patients with mild-to-moderate acne. The study enrolled 60 Russian individuals affected with acne vulgaris (AV) of mild-to-moderate severity divided into two therapeutic groups (half of the patients were female; mean age was 19.5±5.6 years). This study’s findings demonstrate that topical antimicrobial peptides (GDP-20) combined with low doses of systemic isotretinoin mild-to-moderate resulted in considerable improvement of clinical manifestations of mild-to-moderate AV and 3-fold reduction of the disease severity with IGA score 0–1 after 12 weeks. The efficacy of low-dose systemic isotretinoin in combined treatment of mild-to-moderate AV can be improved by using topical application of GDP-20 antimicrobial peptides.