Shen CL, et al. - Osteopenic postmenopausal women were assessed for changes in bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) following supplementation with tocotrienols (TT) for a period of 12 weeks. This supplementation resulted in decreased bone resorption and improved bone turnover rate via suppressing bone remodeling regulators. In addition, data suggested that an inhibition of oxidative stress possibly partly mediated such osteoprotective TT’s impacts.