Tobacco toxicant exposure in cigarette smokers who use or do not use other tobacco products
Drug and Alcohol Dependence Aug 21, 2017
Nollen NL, et al. Â Study authors carried out this investigation to measure biomarkers of nicotine and carcinogen exposure in cigarette smokers who used or did not use other tobacco products (OTP). The results indicated that cigarette-OTP (Cig-OTP) users had lower levels of nicotine and metabolites of a lung carcinogen relative to CigÂOnly users. They observed that concentrations of toxicants among CigÂOTP users were still at levels that place smokers at great risk from the detrimental health effects of smoking.
Methods
- For the purpose of this study, 111 Cig-OTP and 111 cigarette only (Cig Only) users who smoked equivalent cigarettes per day were matched on age (< 40, > = 40), race (African American, White), and gender.
- Members revealed past 7-day daily use of cigarettes and OTP and provided urine for nicotine, cotinine, total nicotine equivalents (TNE) and total NNAL concentrations.
Results
- The results of this study showed that Cig-OTP users reported greater past 7-day tobacco use (15.9 versus 13.0 products/day, p 0.01) however had significantly lower creatinine-normalized nicotine (606 versus 1,301?ng/mg), cotinine (1,063 versus 2,125?ng/mg), TNE (28 versus 57 nmol/mg) and NNAL (251 versus 343?pg/mg) than Cig Only users (p < 0.001).
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