Oates GR, Baker E, Rowe SM, et al. - Across the whole US CF care network population, researchers assessed the contributions of tobacco smoke exposure and socioeconomic factors on lung function deterioration, longitudinally, utilizing data from the CF Foundation Patient Registry. All people who at the end of 2016 were 6–18 years old were included (n = 10,895). For each individual, lung function measures (ppFEV₁) were estimated at each attained age. Findings revealed that independent risk for reduced ppFEV₁ in pediatric patients with CF was conferred by smoke exposure and socioeconomic factors. Experts recommended emphasizing smoking cessation strategies at the time of CF diagnosis and reiteration of these during infancy and early childhood. In disadvantaged families, where the exposure has a disproportionately large influence, interventions may be prioritized.