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TMSB10 can serve as a potential prognosis prediction biomarker and promotes the invasion and angiogenesis of gastric cancer

Journal of Gastroenterology and Hepatology Jun 17, 2021

Yan Z, Yan Q, Song Y, et al. - Researchers investigated thymosin beta 10 (TMSB10) expression in human GC tissues as well as its correlation with clinical pathologic features and prognosis in GC patients. They found that GC cells and tissues exhibited marked overexpression of TMSB10 protein expression, which was related to advanced tumor stage, and lymph nodes metastasis of GC patients. A remarkably shorter survival was experienced by GC patients with high TMSB10 expression. Experts also found that TMSB10 overexpression promoted, while TMSB10 knockdown the proliferation, EMT process as well as angiogenesis of GC cells. Findings emphasize the likely promising utility of TMSB10 as potential prognosis prediction biomarker for the diagnosis of GC and also as a potential treatment target which will facilitate the development of a novel treatment approach against GC.

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