Li W, Wang H, Yu H, et al. - Researchers analyzed the expression and localization of cofilin in a tissue microarray (TMA) of juvenile nasopharyngeal angiofibroma (JNA) specimens, as well as explored its association with clinicopathological features and recurrence. To detect cofilin expression in a TMA of samples from 70 JNA patients and 10 control individuals, immunohistochemistry was performed. Using Pearson's chi-square test, the link between clinicopathological variables and cofilin immunostaining was analyzed. In irregular smooth muscle cells, pericytes, less differentiated stromal cells, and plump cells, cofilin was observed, but not in inactive fibroblasts and mature vascular endothelial cells of JNA specimens. Cofilin presence in JNA was associated with tumor stage and volume of intraoperative hemorrhage. Findings suggested that cofilin is an independent prognostic marker for patients with JNA who have undergone surgical treatment and maybe a novel target for extensive JNA therapy.