França M, et al. – The present study was to observe iron loading within the liver, pancreas, spleen, and bone marrow using magnetic resonance imaging (MRI) transverse relaxation rate, in patients with diffuse liver diseases; to assess the links between iron accumulation in these tissue compartments; and to evaluate the correlation between tissue iron overload and the pattern of hepatic cellular iron distribution. The results of this displayed that patients with chronic diffuse liver diseases have concomitant hepatic, splenic, and bone marrow iron loading. The highest hepatic iron scores and iron inside Kupffer cells were correlated with the highest splenic and bone marrow deposits, demonstrating systemic iron accumulation in the mononuclear phagocytic system.