Zhang Z, Chang M, Song X, et al. - TIPE1 is a newly identified member in the TIPE (TNFAIP8) family that plays an important role in tumorigenesis and immune regulation. Researchers herein investigated its role in ovarian cancer by determining the protein expression spectrum of TIPE1 in normal human tissues and ascertaining its relationship with metastasis in ovarian cancer. The results of IHC staining indicated the presence of TIPE1 protein not only in cytoplasm in most human tissues but also in both cytoplasm and nucleus in squamous epithelium and some epithelial-derived cells with secretory functions, such as esophagus, cervix uteri and ovary, and thyroid gland. In addition, ovarian cancer tissues showed downregulation of TIPE1 protein compared with the paracancerous tissues. More importantly, TIPE1 suppressed tumorigenesis and metastasis of ovarian cancer in vitro and in vivo. Altogether, the findings suggest the suppressor role of TIPE1 in ovarian cancer metastasis, indicating the predictive value of TIPE1 for metastasis and it to be a novel therapeutic target for ovarian cancer.