Arnold JH, Bental T, Greenberg G, et al. - Researchers used a prospectively collected consecutive registry to measure cardiac consequences associated with duration between primary percutaneous coronary intervention (pPCI) of the culprit lesion and staged PCI (sPCI) of nonculprit lesions. Among 3,002 patients managed for ST-elevation myocardial infarction by pPCI, a total of 1,555 with multivessel disease (MVD) needing sPCI were selected. Participants were assigned into quartiles of duration to sPCI: 0–7 days (Q1), 7–22 days (Q2), 22–42 days (Q3), >42 days (Q4), excluding patients who had complete revascularization at the index event. Major adverse cardiac events (MACEs: included all-cause mortality, myocardial infarction, target vessel revascularization, and coronary artery bypass surgery) rates were estimated to be: Q1 - 16.5%, Q2 - 21.2%, Q3 - 25.8%, and Q4 - 30.1%. After regression analysis, sPCI continued to be an independent risk factor for MACE. Findings revealed that MVD cases had an elevated risk of MACE development post-revascularization of nonculprit vessels with increasing time delay between pPCI and sPCI.