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Timing of fluorodeoxyglucose positron emission tomography maximum standardized uptake value for diagnosis of local recurrence of non‐small cell lung cancer after stereotactic body radiation therapy

Cancer Medicine Aug 31, 2020

Tan D, Gill S, Loh N., et al. - This single‐centre retrospective review was carried out to investigate if maximum standardized uptake value (SUVmax) > 5 on 18‐F‐Fluorodeoxyglucose positron emission tomography (FDG PET) can detect local recurrence of non‐small cell cancer (NSCLC) after 9 months following stereotactic body radiation therapy (SBRT). Patients managed with SBRT for stage 1‐2 NSCLC between April 2014 and 2018 were included. Eligible FDG‐PET scans were obtained from 42 of 118 patients treated. At a median of 16 months, local recurrence was diagnosed in 12 patients. Overall 71 FDG‐PET scans were performed after 9 months. Significantly higher median SUVmax was reported for patients with local recurrence. Overall, the observed sensitivity and specificity of SUVmax > 5 on FDG‐PET scan to identify local recurrence of NSCLC was found to be good after 6 months, but was highest after 9 months following SBRT.

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