Martin KA, Molsberry R, Cuttica MJ, et al. - Researchers sought to report on the trends in death rates caused by pulmonary embolism (PE) in the United States, overall and by gender‐race, regional, and age subgroups. Nationwide death certificate data were employed from Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research to determine age‐adjusted mortality rates for PE as underlying cause of death from 1999 to 2018. Statistical trends and average annual percent change were determined using the Joinpoint regression program. After an inflection point in 2008, trends in PE mortality rates reversed. Findings revealed an increase in PE mortality over the past decade and persistence of racial and geographic disparities. Nearly 2‐fold higher age‐adjusted mortality rates were reported for black men and women compared with White men and women, respectively, before and after the inflection point. Geographical regions were identified to have similar trends. During the study period, age‐adjusted mortality rates increased for younger adults (25–64 years) and remained stable for older adults (> 65 years). Findings emphasize recognizing the underlying drivers of these changing mortality trends and persistently observed disparities to reduce the burden of PE‐related mortality, especialy premature preventable PE deaths among younger adults (< 65 years).