Regauer S, et al. - Researchers investigated the impact of TP53 gene mutations in recurrent HPV-negative vulvar squamous cell carcinomas via analyzing TP53 gene mutations in archival tissues of 24 primary squamous cell carcinoma and local vulvar recurrences arising in chronic inflammatory dermatoses by analyzing the full coding sequence of the TP53 gene and correlated with disease-free survival. In this work, the residual vulvar dermatosis showed recurrence of squamous cell carcinomas independent of TP53 gene mutational status of the primary squamous cell carcinoma. They noted different TP53 gene mutations in the majority of TP53 gene mutated cancers recurrences, some of them more complex, and patients with p53 wild-type developed TP53 gene mutations in the recurrent squamous cell carcinomas. De novo oncogenic events/carcinogenesis may represent a change of TP53 gene mutational status after > 5 years. In patients with p53 wild-type primary squamous cell carcinoma, longer disease-free intervals suggest the utility of TP53 gene mutational status as a prognostic marker for disease-free intervals.