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Time-dependent incidence and risk for myocardial infarction in patients with alcoholic cirrhosis

European Journal of Clinical Investigation Feb 06, 2020

Deleuran T, et al. - Researchers evaluated the time-dependent incidence and risk for myocardial infarction (MI) in individuals with alcoholic cirrhosis. They analyzed data from national healthcare registries to examine all Danes diagnosed with alcoholic cirrhosis in 1996–2014. Five controls were paired to each of them based sex and age. Cox regression was applied to evaluate the incidence rate ratio of MI adjusted for potential cardiovascular confounders. A total of 22,867 individuals (67% men) with a median age of 57 years were recruited in this study. The incidence rate ratio of MI was elevated to 1.24, driven by the impact among women and those with the most severe cirrhosis during the first year of follow-up. The incidence rate of MI was raised the first year following a diagnosis of alcoholic cirrhosis, especially in women and those with most severe liver disease. The MI-risk was not raised due to the competing risk of non-MI mortality.

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