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Time-dependent changes in extra-domain A-fibronectin concentration and relative amounts of fibronectin-fibrin complexes in plasma of patients with peripheral arterial disease after endovascular revascularisation

International Wound Journal Mar 23, 2018

Pupek M, et al. - Given that fibronectin (FN) may be involved in time- and stage-dependent and inter-related controlled processes of inflammation, coagulation, and wound healing accompanying peripheral arterial disease (PAD). Researchers analyzed the FN and FN-containing extra-domain A (EDA-FN), macromolecular FN-fibrin complexes, and FN monomer in the plasma of PAD patients, including the patients with restenosis, for 37-months after revascularization. Findings suggested a potential diagnostic value of high levels of EDA-FN and FN-fibrin complexes in the management of PAD patients after revascularization, predicting restenosis risk.
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