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Time-centered approach to understanding risk factors for the progression of CKD

Clinical Journal of the American Society of Nephrology Apr 22, 2018

Ku E, et al. - In participants of the Chronic Renal Insufficiency Cohort, median time spent in each of CKD stages 3a–5 was estimated and how the time differs according to risk factors associated with progression of disease was investigated. Median follow-up of 9.5 years was carried out, during which it was noted that participants spent longer in earlier rather than later CKD stages, ranging from a median of 7.9 years in stage 3a to 0.8 years in stage 5. Based on risk factors and stage of disease, marked variations were noted in the time spent in the different stages of CKD. For illustration, systolic BP ≥140 mm Hg vs systolic BP <140 mm Hg was found to be related to 6.1 years shorter time spent in stage 3a, 3.3 years shorter time in stage 3b, but only 2.4 months shorter time in stage 5.
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