Davis HC, et al. - This trial was conducted to determine the relationship between time from injury to anterior cruciate ligament (ACL) reconstruction (Time^{Injury–ACLR}) and biochemical markers of cartilage metabolism and inflammation 6 months after ACL reconstruction (ACLR). In males but not females, greater time between injury and ACL reconstruction was noted to be related to greater serum C2C:CPII six months following ACLR. In addition, IL-6, MMP-3, and ARGS levels were not related to Time^{Injury–ACLR} in males or females. In males, collagen metabolism could be affected by the time between ACL injury and ACLR.